{"version":3,"file":"fHXDTZC-.js","sources":["../../../../views/tool/views/mouse-pheno-predict/childrens/middle/src/composable.ts","../../../../views/tool/views/mouse-pheno-predict/childrens/middle/index.vue","../../../../views/tool/views/mouse-pheno-predict/childrens/model/components/preview/src/dispost.ts","../../../../views/tool/views/mouse-pheno-predict/childrens/model/components/preview/src/composable.ts","../../../../views/tool/views/mouse-pheno-predict/childrens/model/components/preview/index.vue","../../../../views/tool/views/mouse-pheno-predict/childrens/model/components/gene/src/composable.ts","../../../../views/tool/views/mouse-pheno-predict/childrens/model/components/gene/index.vue","../../../../views/tool/views/mouse-pheno-predict/childrens/model/components/protein/src/options.ts","../../../../views/tool/views/mouse-pheno-predict/childrens/model/components/protein/src/composable.ts","../../../../views/tool/views/mouse-pheno-predict/childrens/model/components/protein/index.vue","../../../../views/tool/views/mouse-pheno-predict/childrens/model/components/transcript/src/composable.ts","../../../../views/tool/views/mouse-pheno-predict/childrens/model/components/transcript/index.vue","../../../../views/tool/views/mouse-pheno-predict/childrens/model/src/composable.ts","../../../../views/tool/views/mouse-pheno-predict/childrens/model/index.vue","../../../../views/tool/views/mouse-pheno-predict/index.vue"],"sourcesContent":["import type { SearchGeneModal } from \"@/components/windows\";\n\nexport const useComposable = () => {\n    //* 响应式变量\n    const refs = {\n        keyword: ref<string>(\"\"),\n        modal: ref<InstanceType<typeof SearchGeneModal>>(),\n    };\n\n    //* 函数列表\n    const methods = {\n        //* 基因窗口选择回调\n        change: (data: any) => routerPush({ name: \"MousePhenoPredict\", query: { id: data?.id || \"\" } }),\n        //* 搜索事件回调\n        search: () => {\n            refs.modal.value?.open(refs.keyword.value);\n        },\n    };\n\n    return { refs, methods };\n};\n","<template>\n    <div class=\"search-middle container\">\n        <!-- * 标题 -->\n        <div class=\"title-2 font-bold color-1\">{{ $t(\"MousePhenoPredict\") }}</div>\n        <div class=\"title-5 font-bold color-1\">{{ $t(\"Placeholder.PleaseInputTypeInterest\", { type: \"Gene\" }) }}</div>\n\n        <!-- * 搜索框 -->\n        <ToolSearch size=\"large\" v-model=\"keyword\" :placeholder=\"$t('Placeholder.SearchGeneOrID', 2)\" @search=\"methods.search\" />\n\n        <!-- * 描述信息 -->\n        <div class=\"search-introduce\">{{ $t(\"MousePhenoPredictIntroduction\") }}</div>\n\n        <!-- * 搜索窗口 -->\n        <search-gene-modal ref=\"modal\" trigger=\"none\" :selector=\"[{ key: 'taxonomy_id', value: '10090' }]\" @change=\"methods.change\" />\n    </div>\n</template>\n\n<script lang=\"ts\" setup>\n//* 公共组件\nimport { SearchGeneModal } from \"@/components/windows\";\nimport { ToolSearch } from \"@/components/controls\";\n//* 组件属性\nimport { useComposable } from \"./src/composable\";\n\n//* 组合函数?\nconst { refs, methods } = useComposable();\nconst { modal, keyword } = refs;\n</script>\n\n<style lang=\"less\" scoped>\n@import url(\"./index.less\");\n</style>\n","//* 概况图\n//- 2. 绘制逻辑\n//* 1. Exon尺寸 40 ~ 320, 默认比例 2:1\n//* 2. Intron尺寸 40, 固定40尺寸, 动态比例\n\n//* 详细图\n//- 2. 绘制逻辑\n//* 2.1 Exon尺寸 40 ~ 320, 默认比例 2:1\n//* 2.2 Intron尺寸 25 ~ 80, 最小25最大80尺寸, 动态比例\n//* 2.2.1 小于100bp时长度为25 ~ 50, 默认比例 2:1\n//* 2.2.2 大于100bp时长度固定80, 取前后100bp以2:1比例绘制, 其余按动态比例的bp:30绘制\n\n//* 新增内容\n//- 1. 基于基因长度补充Mrna前后的Intron\n\n/* eslint-disable no-dupe-class-members */\nexport class disposeData {\n    data: any[] = [];\n    dictionaries: any[] = [];\n\n    cds;\n    size;\n    view;\n    exons;\n    length;\n\n    constructor(data: any, view = {}) {\n        this.view = view; //? 视图参数\n        this.cds = data.cds || []; //? cds数据\n        this.size = 0; //? 绘制图像实际尺寸\n        this.data = []; //? 实例化class后的预处理数据\n        this.exons = data.exons || []; //? exon数据\n        this.length = data.length || 0; //? 基因长度\n        this.dictionaries = []; //? 绘图字典, 用于坐标计算与绘图\n\n        //- 1. 数据分类生成Exon, Intron字典集\n        this.#disposeClassify();\n    }\n\n    //* 数据分类生成Exon, Intron字典集\n    #disposeClassify() {\n        //- 1. 初始化配置数据\n        const config = { cdsPos: 1, eggPos: 1, eggDiff: 0 };\n\n        //- 2. 遍历Exons生成Exon, Intron字典集\n        this.data = [];\n        this.exons.forEach((exon: number[], index: number) => {\n            const size = exon[1] - exon[0] + 1;\n            const front = this.exons[index - 1] || [];\n            const frontEnd = front?.[1] || 0;\n            //- 2.1 判断Exon之前是否存在一段Intron\n            if (exon[0] - frontEnd > 1) {\n                this.data.push({ start: frontEnd + 1, end: exon[0] - 1, size: exon[0] - frontEnd - 2, type: \"intron\" });\n            }\n\n            //- 2.2 添加Exon数据, 并处理cds数据生成强关联的蛋白数据与cds数据\n            this.data.push(this.#disposeExon({ start: exon[0], end: exon[1], size: size, type: \"exon\", name: `E${index + 1}` }, config));\n        });\n\n        //- 2.3 判断尾部是否存在一段Intron\n        const queen = this.data.slice(-1)[0] || {};\n        if (queen && queen.end < this.length) {\n            this.data.push({ start: queen.end + 1, end: this.length, size: this.length - queen.end, type: \"intron\" });\n        }\n    }\n\n    //* 将cds和exon数据进行强关联, 并计算出蛋白的坐标\n    #disposeExon(data: any, config: any) {\n        //- 1. 完全相信后端CDS坐标没问题, 有问题找后端\n        for (let i in this.cds) {\n            const value = this.cds[i];\n            if (data.start <= value[0]) {\n                //- 1.1 Exon起始坐标在CDS左侧\n                if (data.end >= value[0] && value[1] >= data.end) {\n                    //- 1.1.1 Exon终点坐标在CDS内部\n                    data.cds = { end: data.end, start: value[0], size: data.end - value[0] + 1 };\n                } else if (data.end >= value[1]) {\n                    //- 1.1.2 Exon终点坐标在CDS右侧\n                    data.cds = { end: value[1], start: value[0], size: value[1] - value[0] + 1 };\n                }\n            } else if (data.start <= value[1]) {\n                //- 1.2 Exon起始坐标在CDS内部\n                if (data.end >= value[0] && value[1] >= data.end) {\n                    //- 1.2.1 Exon终点坐标在CDS内部\n                    data.cds = { end: data.end, start: data.start, size: data.end - data.start + 1 };\n                } else if (data.end >= value[1]) {\n                    //- 1.2.2 Exon终点坐标在CDS右侧\n                    data.cds = { start: data.start, end: value[1], size: value[1] - data.start + 1 };\n                }\n            }\n\n            //- 2. 判断是否存在CDS区域, 存在则计算CDS相对坐标, 蛋白相对坐标并返回数据\n            if (data.cds) {\n                const diff = data.cds.size - config.eggDiff;\n                data.cds.rEnd = config.cdsPos + data.cds.size - 1;\n                data.cds.rStart = config.cdsPos;\n                data.eggWhite = { start: config.eggPos, end: config.eggPos + Math.ceil(diff / 3) - 1 };\n                config.cdsPos = config.cdsPos + data.cds.size;\n                config.eggPos = config.eggPos + Math.ceil(diff / 3);\n                if (diff % 3 != 0) {\n                    config.eggDiff = 3 - (diff % 3);\n                }\n\n                return data;\n            }\n        }\n\n        return data;\n    }\n\n    //* 概括图绘图数据计算函数\n    disposeOverviewData() {\n        //- 1. 初始化数据\n        this.size = 0;\n        this.dictionaries = [];\n        const config = { offset: 0 };\n\n        //- 2. 遍历预处理数据生成绘图数据\n        this.data.forEach((value) => {\n            switch (value.type) {\n                case \"intron\": {\n                    this.size += 64;\n                    this.dictionaries.push(Object.assign(value, { width: 64, ratio: 64 / value.size, offset: config.offset }));\n                    config.offset += 64;\n                    break;\n                }\n\n                case \"exon\": {\n                    const width = value.size * 0.5;\n                    const result = Object.assign(value, { width: width, ratio: 0.5, offset: config.offset });\n                    if (width < 40) {\n                        result.width = 40;\n                        result.ratio = 40 / value.size;\n                    } else if (width > 320) {\n                        result.width = 320;\n                        result.ratio = 320 / value.size;\n                    }\n\n                    this.dictionaries.push(result);\n                    this.size += result.width;\n                    config.offset += result.width;\n                    break;\n                }\n            }\n        });\n    }\n\n    //* 详细图绘图数据计算函数\n    disposeDetailsData() {\n        //- 1. 初始化数据\n        this.size = 0;\n        this.dictionaries = [];\n        const config = { offset: 0 };\n\n        //- 2. 遍历预处理数据生成绘图数据\n        this.data.forEach((value) => {\n            switch (value.type) {\n                case \"intron\": {\n                    const result = Object.assign(value, { ratio: 0.5, offset: config.offset });\n                    if (value.size <= 100) {\n                        result.width = value.size * 0.5;\n                        if (result.width < 25) {\n                            result.width = 25;\n                            result.ratio = 25 / value.size;\n                        }\n                    } else {\n                        result.omit = 30 / (value.size - 100);\n                        result.width = 80;\n                    }\n\n                    this.dictionaries.push(result);\n                    this.size += result.width;\n                    config.offset += result.width;\n                    break;\n                }\n\n                case \"exon\": {\n                    const width = value.size * 0.5;\n                    const result = Object.assign(value, { width: width, ratio: 0.5, offset: config.offset });\n                    if (width < 40) {\n                        result.width = 40;\n                        result.ratio = 40 / value.size;\n                    } else if (width > 320) {\n                        result.width = 320;\n                        result.ratio = 320 / value.size;\n                    }\n\n                    this.dictionaries.push(result);\n                    this.size += result.width;\n                    config.offset += result.width;\n                    break;\n                }\n            }\n        });\n    }\n\n    //* 坐标转换函数\n    disposePos(site: number, option: any) {\n        //- 数据初始化\n        option = option || { align: \"left\" };\n        //- return数据初始化\n        const result = { offset: 0, data: null, site: 0 };\n        //- 遍历dictionaries获取坐标\n        for (let i = 0, l = this.dictionaries.length; i < l; i++) {\n            const value = this.dictionaries[i];\n            if (site <= value.end && site >= value.start) {\n                result.data = value;\n                result.site = site;\n\n                //- Intron省略计算处理\n                if (value.omit) {\n                    //- 获取当前偏移\n                    result.offset = value.offset;\n\n                    //- 左侧横线区域计算\n                    if (site - value.start < 50) {\n                        result.offset += (site - value.start) * value.ratio;\n                    } else {\n                        result.offset += 25;\n                    }\n\n                    //- 中间省略与右侧横线区域计算\n                    if (site - value.start > 50) {\n                        if (value.end - site >= 50) {\n                            result.offset += (site - value.start) * value.omit;\n                        } else {\n                            result.offset += 30 + (site - value.end + 51) * value.ratio;\n                        }\n                    }\n                } else {\n                    result.offset = value.offset + (site - value.start) * value.ratio;\n                }\n\n                //- 边界检测\n                if (result.site < value.start) result.site = value.start;\n                if (result.site > value.end) result.site = value.end;\n\n                switch (option.align) {\n                    case \"right\": {\n                        result.offset += value.ratio;\n                        break;\n                    }\n\n                    case \"center\": {\n                        result.offset += value.ratio / 2;\n                        break;\n                    }\n                }\n\n                return result;\n            }\n        }\n\n        return result;\n    }\n}\n","import Konva from \"konva\";\nimport type { PreViewBarOption } from \"../index\";\nimport type { UiTooltipFunction } from \"various-ui\";\n\nimport { disposeData } from \"./dispost\";\n\nexport const useComposable = () => {\n    //* 获取i18n\n    const i18n = useI18n();\n\n    //* 响应式变量\n    const refs = {\n        mode: ref<string>(\"overview\"),\n\n        mainNode: ref<HTMLDivElement>(),\n        tooltipNode: ref<InstanceType<typeof UiTooltipFunction>>(),\n\n        mrna: ref<Konva.Group>(),\n        main: ref<Konva.Layer>(),\n        stage: ref<Konva.Stage>(),\n        mutation: ref<Konva.Group>(),\n\n        info: ref<any>(),\n        offset: ref<number>(0),\n        content: ref<any>(),\n        drawing: ref<any>(),\n    };\n\n    //* Bar配置项\n    const bar = reactive<PreViewBarOption>({ el: undefined, size: 0, ratio: 0 });\n\n    //* 函数列表\n    const methods = {\n        //* 初始化函数\n        init: function (data: any) {\n            refs.drawing.value = new disposeData(data, { width: refs.mainNode.value?.clientWidth || 0 });\n            methods.draw(\"overview\");\n        },\n\n        //* 绘制函数\n        draw: function (mode: string) {\n            if (!refs.mainNode.value) return;\n\n            //- 1. 初始化舞台与场景\n            if (refs.stage.value) {\n                refs.offset.value = 0;\n                refs.main.value?.destroyChildren();\n            } else {\n                refs.stage.value = new Konva.Stage({ container: refs.mainNode.value, width: refs.drawing.value.view.width, height: 131 });\n                refs.main.value = new Konva.Layer();\n            }\n\n            if (!refs.main.value || !refs.stage.value) return;\n\n            //- 2. 根据绘制的模式进行不同的数据处理\n            switch (mode) {\n                case \"overview\":\n                    refs.mode.value = \"overview\";\n                    refs.drawing.value.disposeOverviewData();\n                    break;\n                case \"details\":\n                    refs.mode.value = \"details\";\n                    refs.drawing.value.disposeDetailsData();\n                    break;\n            }\n\n            //- 3. 绘制Mrna\n            refs.mrna.value = new Konva.Group();\n            refs.content.value = new Konva.Group();\n            refs.drawing.value.dictionaries.forEach((value: any) => {\n                switch (value.type) {\n                    case \"intron\":\n                        return methods.drawIntron(value);\n                    case \"exon\":\n                        return methods.drawExon(value);\n                }\n            });\n\n            //- 4. 绘制滚动条\n            methods.drawScrollBar();\n\n            //- 5. 初始化突变信息\n            refs.mutation.value = new Konva.Group();\n\n            //- 将场景添加入舞台中\n            refs.mrna.value.add(refs.mutation.value);\n            refs.mrna.value.add(refs.content.value);\n            refs.main.value.add(refs.mrna.value);\n            refs.stage.value.add(refs.main.value);\n        },\n\n        //* 绘制Exon\n        drawExon: function (value: any) {\n            //- 1. 生成容器\n            const container = new Konva.Group();\n\n            //- 2. 绘制线框\n            container.add(\n                new Konva.Rect({\n                    x: value.offset + 0.5,\n                    y: 60.5,\n                    width: value.width - 1,\n                    height: 23,\n                    stroke: \"#999999\",\n                    strokeWidth: 1,\n                    cornerRadius: 2,\n                })\n            );\n\n            //- 3. 绘制CDS区域\n            if (value.cds) {\n                //- 2.1 初始化数据\n                const end = refs.drawing.value.disposePos(value.cds.end, { align: \"right\" });\n                const start = refs.drawing.value.disposePos(value.cds.start);\n                const radius = [0, 0, 0, 0];\n                //- 2.2 判断CDS左侧是否需要圆角\n                if (value.cds.start == value.start) {\n                    radius[0] = 2;\n                    radius[3] = 2;\n                }\n                //- 2.2 判断CDS右侧是否需要圆角\n                if (value.cds.end == value.end) {\n                    radius[1] = 2;\n                    radius[2] = 2;\n                }\n                //- 2.3 绘制\n                container.add(\n                    new Konva.Rect({ x: start.offset, y: 60, width: end.offset - start.offset, height: 24, fill: \"#00C7C8\", cornerRadius: radius })\n                );\n            }\n\n            //- 4. 绘制文本\n            const content = new Konva.Text({\n                x: value.offset + value.width / 2,\n                y: 66,\n                fontFamily: \"Noto Sans CJK Regular\",\n                fontSize: 14,\n                fill: \"#4a4a4a\",\n                text: value.name,\n            });\n\n            refs.content.value.add(content.offsetX(content.getTextWidth() / 2));\n\n            container.on(\"mouseenter\", (ev) => {\n                refs.info.value = value;\n                refs.tooltipNode.value?.show(\"start\", {\n                    pageX: ev.evt.x,\n                    pageY: ev.evt.y,\n                    initialization: true\n                });\n            });\n\n            container.on(\"mousemove\", (ev) => {\n                refs.tooltipNode.value?.show(\"start\", {\n                    pageX: ev.evt.x,\n                    pageY: ev.evt.y,\n                    initialization: true\n                });\n            });\n\n            container.on(\"mouseleave\", (ev) => {\n                refs.tooltipNode.value?.hidden();\n            });\n\n            //- 6. 将容器添加进场景中\n            refs.mrna.value?.add(container);\n        },\n\n        //* 绘制Intron\n        drawIntron: function (value: any) {\n            if (value.omit) {\n                refs.mrna.value?.add(new Konva.Rect({ x: value.offset, y: 71, width: 25, height: 2, fill: \"#4a4a4a\" }));\n                refs.mrna.value?.add(new Konva.Rect({ x: value.offset + 31, y: 71, width: 2, height: 2, fill: \"#4a4a4a\", rotation: 2 }));\n                refs.mrna.value?.add(new Konva.Rect({ x: value.offset + 39, y: 71, width: 2, height: 2, fill: \"#4a4a4a\", rotation: 2 }));\n                refs.mrna.value?.add(new Konva.Rect({ x: value.offset + 47, y: 71, width: 2, height: 2, fill: \"#4a4a4a\", rotation: 2 }));\n                refs.mrna.value?.add(new Konva.Rect({ x: value.offset + 55, y: 71, width: 25, height: 2, fill: \"#4a4a4a\" }));\n            } else {\n                refs.mrna.value?.add(new Konva.Rect({ x: value.offset, y: 71, width: value.width, height: 2, fill: \"#4a4a4a\" }));\n            }\n        },\n\n        //* 绘制滚动条\n        drawScrollBar: function () {\n            if (refs.drawing.value.size > refs.drawing.value.view.width) {\n                //- 1. 计算Bar尺寸\n                bar.ratio = (refs.drawing.value.view.width - 2) / refs.drawing.value.size;\n                bar.size = bar.ratio * refs.drawing.value.view.width;\n\n                //- 2. 绘制滚动条背景框\n                const wireframe = new Konva.Rect({ x: 0, y: 112, width: refs.drawing.value.view.width, height: 16, fill: \"#F4F4F4\" });\n\n                //- 3. 绘制Bar\n                bar.el = new Konva.Rect({\n                    x: 1,\n                    y: 110,\n                    width: bar.size,\n                    height: 20,\n                    fill: \"#fff\",\n                    stroke: \"#999999\",\n                    strokeWidth: 1,\n                    fillAfterStrokeEnabled: true,\n                });\n\n                //- 4. 悬浮鼠标样式修改\n                bar.el.on(\"mouseenter\", (ev: any) => {\n                    ev.evt.target.style.cursor = \"pointer\";\n                    bar.el?.stroke(\"#666666\");\n                });\n                bar.el.on(\"mouseleave\", (ev: any) => {\n                    ev.evt.target.style.cursor = \"auto\";\n                    bar.el?.stroke(\"#999999\");\n                });\n\n                //- 5. Bar拖动反馈\n                bar.el.on(\"mousedown\", (ev: any) => {\n                    const clientX = ev.evt.clientX;\n                    const offsetX = refs.offset.value;\n                    //- 鼠标移动反馈事件, 边界检测\n                    document.onmousemove = (ev) => {\n                        //- 偏移记录\n                        refs.offset.value = methods.BoundaryDetection(offsetX + ev.clientX - clientX);\n                        //- 触发移动反馈事件\n                        bar.el?.offsetX(-refs.offset.value);\n                        refs.mrna.value?.offsetX(refs.offset.value / bar.ratio);\n                    };\n                    //- 鼠标松开反馈事件, 左右端20%的区域触发Mrna偏移, 偏移边界检测\n                    document.onmouseup = () => {\n                        //- 清空事件\n                        document.onmouseup = null;\n                        document.onmousemove = null;\n                    };\n                });\n\n                refs.main.value?.add(wireframe);\n                refs.main.value?.add(bar.el as Konva.Rect);\n            } else {\n                bar.el = undefined;\n                bar.size = 0;\n                bar.ratio = 0;\n            }\n        },\n\n        //* 绘制预测点\n        drawPos: function (data: any) {\n            //- 1. 检测是否为详情图\n            if (refs.mode.value == \"overview\") {\n                methods.draw(\"details\");\n            }\n\n            //- 2. 旧数据清除与添加\n            refs.mutation.value?.destroyChildren();\n\n            //- 3. 获取start与end的位置\n            const end = refs.drawing.value.disposePos(data.end, { align: \"right\" });\n            const start = refs.drawing.value.disposePos(data.start);\n\n            //- 4. 存在Bar时才进行偏移定位\n            if (bar.el) {\n                let offset = 0;\n                if (start.offset < refs.drawing.value.view.width / 2) {\n                    refs.offset.value = 0;\n                } else if (start.offset > refs.drawing.value.size - refs.drawing.value.view.width / 2) {\n                    offset = refs.drawing.value.size - refs.drawing.value.view.width;\n                    refs.offset.value = offset * bar.ratio;\n                } else {\n                    offset = start.offset - refs.drawing.value.view.width / 2;\n                    refs.offset.value = offset * bar.ratio;\n                }\n\n                bar.el.offsetX(-refs.offset.value);\n                refs.mrna.value?.offsetX(offset);\n            }\n\n            //- 5. 绘制预测点位\n            //- 5.1 数据初始化\n            const ref = data.ref ? (data.ref.length > 10 ? `${data.ref.slice(0, 3)}···${data.ref.slice(-3)}` : data.ref) : \"--\";\n            const alt = data.alt ? (data.alt.length > 10 ? `${data.alt.slice(0, 3)}···${data.alt.slice(-3)}` : data.alt) : \"del\";\n            const config = {\n                content: [`${i18n.t(\"BioTools.Mutation\")}: ${ref}${alt == \"del\" ? \"\" : ` > ${alt}`}`],\n                offset: start.offset + (end.offset - start.offset) / 2,\n                size: 0,\n            };\n            if (ref.length > 10 || alt.length > 10) {\n                if (alt === \"del\") {\n                    config.content.push(`${ref.length}bp`);\n                } else {\n                    config.content.push(` (${ref.length}bp > ${alt.length}bp)`);\n                }\n            }\n\n            //- 5.2 绘制线条区域\n            refs.mutation.value?.add(\n                new Konva.Rect({ x: start.offset, y: 32, width: 1, height: start.data.type == \"intron\" ? 40 : 28, fill: \"#ce2424\" })\n            );\n            refs.mutation.value?.add(\n                new Konva.Rect({ x: end.offset - 1, y: 32, width: 1, height: end.data.type == \"intron\" ? 40 : 28, fill: \"#ce2424\" })\n            );\n\n            //- 5.3 初始化文本\n            const mutation = new Konva.Text({\n                y: 0,\n                height: 32,\n                fontFamily: \"Noto Sans CJK Regular\",\n                fontSize: 14,\n                fill: \"#ffffff\",\n                align: \"center\",\n                verticalAlign: \"middle\",\n                text: config.content.join(\"\"),\n            });\n\n            //- 5.4 计算文本偏移位置\n            config.size = mutation.getTextWidth() + 32;\n            if (config.size < end.offset - start.offset + 16) {\n                config.size = end.offset - start.offset + 16;\n            }\n\n            //- 5.5 处理边界问题并绘制突变信息\n            mutation.width(config.size);\n            if (config.offset - config.size / 2 < 0) {\n                refs.mutation.value?.add(new Konva.Rect({ x: 0, y: 0, width: config.size, height: 32, fill: \"#ce2424\", cornerRadius: 2 }));\n                refs.mutation.value?.add(mutation.x(0));\n            } else if (config.offset + config.size > refs.drawing.value.size) {\n                const offsetX = refs.drawing.value.size - config.size;\n                refs.mutation.value?.add(new Konva.Rect({ x: offsetX, y: 0, width: config.size, height: 32, fill: \"#ce2424\", cornerRadius: 2 }));\n                refs.mutation.value?.add(mutation.x(offsetX));\n            } else {\n                const offsetX = config.offset - config.size / 2;\n                refs.mutation.value?.add(new Konva.Rect({ x: offsetX, y: 0, width: config.size, height: 32, fill: \"#ce2424\", cornerRadius: 2 }));\n                refs.mutation.value?.add(mutation.x(offsetX));\n            }\n\n            //- 6. 计算预测点位经过的Exon并绘制预测区域\n            refs.drawing.value.dictionaries.map((value: any) => {\n                if (value.type == \"exon\") {\n                    if (data.start <= value.end && data.start >= value.start) {\n                        if (data.end <= value.end && data.end >= value.start) {\n                            const start = refs.drawing.value.disposePos(data.start);\n                            const end = refs.drawing.value.disposePos(data.end, { align: \"right\" });\n                            refs.mutation.value?.add(\n                                new Konva.Rect({ x: start.offset, y: 60, width: end.offset - start.offset, height: 24, fill: \"#FFD40B\" })\n                            );\n                        } else {\n                            const start = (data.start - value.start) * value.ratio;\n                            refs.mutation.value?.add(\n                                new Konva.Rect({\n                                    x: value.offset + start,\n                                    y: 60,\n                                    width: value.width - start,\n                                    height: 24,\n                                    cornerRadius: [0, 2, 2, 0],\n                                    fill: \"#FFD40B\",\n                                })\n                            );\n                        }\n                    }\n\n                    if (data.end <= value.end && data.end >= value.start && data.start <= value.start) {\n                        refs.mutation.value?.add(\n                            new Konva.Rect({\n                                x: value.offset,\n                                y: 60,\n                                width: (data.end - value.start + 1) * value.ratio,\n                                height: 24,\n                                cornerRadius: [2, 0, 0, 2],\n                                fill: \"#FFD40B\",\n                            })\n                        );\n                    }\n\n                    if (data.start <= value.start && data.end >= value.end) {\n                        refs.mutation.value?.add(\n                            new Konva.Rect({ x: value.offset, y: 60, width: value.width, height: 24, cornerRadius: 2, fill: \"#FFD40B\" })\n                        );\n                    }\n                }\n            });\n\n            refs.mutation.value?.on(\"mouseenter\", (ev: any) => {\n                refs.info.value = data;\n                refs.tooltipNode.value?.show(\"start\", {\n                    pageX: ev.evt.x,\n                    pageY: ev.evt.y,\n                    initialization: true\n                });\n            });\n\n            refs.mutation.value?.on(\"mousemove\", (ev: any) => {\n                refs.tooltipNode.value?.show(\"start\", {\n                    pageX: ev.evt.x,\n                    pageY: ev.evt.y,\n                    initialization: true\n                });\n            });\n\n            refs.mutation.value?.on(\"mouseleave\", (ev: any) => {\n                refs.tooltipNode.value?.hidden();\n            });\n        },\n\n        //* 边界检测函数\n        BoundaryDetection: function (offset: number): number {\n            //- 1. 检测左侧贴边\n            //- 1.1. 当mrna未进行偏移时最小值为0\n            if (offset < 0) {\n                return 0;\n            } else if (offset + bar.size > refs.drawing.value.view.width - 2) {\n                return refs.drawing.value.view.width - bar.size - 2;\n            }\n\n            //- 偏移记录\n            return offset;\n        },\n    };\n\n    return { refs, methods };\n};\n","<template>\n    <div class=\"vpm-preview\">\n        <UiTooltipFunction ref=\"tooltipNode\" class-extra-name=\"vpm-model-tooltip\">\n            <template #default>\n                <!-- 画布 -->\n                <div class=\"vpm-preview-canvas\" ref=\"mainNode\"></div>\n            </template>\n            <template #content>\n                <div class=\"vpm-preview-info-title font-bold\">Exon{{ info.number }}</div>\n                <div class=\"vpm-preview-info-layout\">\n                    <div class=\"vpm-preview-info-label\">Gene</div>\n                    <div class=\"vpm-preview-info-value\">{{ info.start }} - {{ info.end }}</div>\n                </div>\n                <div class=\"vpm-preview-info-layout\" v-show=\"info.cds\">\n                    <div class=\"vpm-preview-info-label\">CDS</div>\n                    <div class=\"vpm-preview-info-value\">{{ info.cds && info.cds.rStart }} - {{ info.cds && info.cds.rEnd }}</div>\n                </div>\n                <div class=\"vpm-preview-info-layout\" v-show=\"info.eggWhite\">\n                    <div class=\"vpm-preview-info-label\">Protein</div>\n                    <div class=\"vpm-preview-info-value\">{{ info.eggWhite && info.eggWhite.start }} - {{ info.eggWhite && info.eggWhite.end }}</div>\n                </div>\n                <div class=\"vpm-preview-info-layout\" v-show=\"info.ref\">\n                    <div class=\"vpm-preview-info-label\">Reference</div>\n                    <div class=\"vpm-preview-info-value\" style=\"word-break: break-all\">{{ info.ref }}</div>\n                </div>\n                <div class=\"vpm-preview-info-layout\" v-show=\"info.alt\">\n                    <div class=\"vpm-preview-info-label\">Alteration</div>\n                    <div class=\"vpm-preview-info-value\" style=\"word-break: break-all\">{{ info.alt }}</div>\n                </div>\n            </template>\n        </UiTooltipFunction>\n    </div>\n</template>\n\n<script lang=\"ts\" setup>\nimport { UiTooltipFunction } from \"various-ui\";\nimport { useComposable } from \"./src/composable\";\n\nconst { refs, methods } = useComposable();\nconst { info, mainNode, tooltipNode } = refs;\n\ndefineExpose({ init: methods.init, drawPos: methods.drawPos });\n</script>\n\n<style lang=\"less\" scoped>\n.vpm-preview {\n    :deep(.ui-tooltip-container) {\n        width: 100%;\n    }\n}\n</style>\n\n<style lang=\"less\">\n.vpm-model-tooltip {\n    padding: 16px 24px;\n    .vpm-preview-info-title {\n        color: var(--uicolor-font-1);\n        font-size: 16px;\n        line-height: 24px;\n        margin-bottom: 8px;\n    }\n\n    .vpm-preview-info-layout {\n        display: flex;\n        margin-bottom: 4px;\n        justify-content: space-between;\n        .vpm-preview-info-label {\n            margin-right: 8px;\n        }\n    }\n}\n</style>\n","import type { UiForm, UiInput, UiTypes } from \"various-ui\";\n\nexport const useComposable = (emit: { (event: \"redraw\", data: any): void }) => {\n    //* 获取I18n\n    const i18n = useI18n();\n\n    //* 响应式变量\n    const refs = {\n        show: ref<boolean>(false),\n\n        dictionaries: ref<any>({}), //? 字典\n        candidate: ref<UiTypes.candidate[]>([]), //? 候选项\n        original: ref<any>({}), //? 原始数据\n\n        cPlaceholder: { start: i18n.t(\"BioTools.StartSite\"), end: i18n.t(\"BioTools.EndSite\") },\n    };\n\n    //* 表单数据\n    const data = reactive({\n        ref: \"\",\n        alt: \"\",\n        coordinate: <{ start?: number; end?: number }>{},\n    });\n\n    //* 节点\n    const nodes = {\n        alt: ref<InstanceType<typeof UiInput>>(),\n        form: ref<InstanceType<typeof UiForm>>(),\n    };\n\n    //* 表单校验规则\n    const rules: { [name: string]: UiTypes.verifyRule[] } = {\n        coordinate: [\n            {\n                trigger: \"change\",\n                verify: (data: any) => {\n                    const seqLen = refs.dictionaries.value?.sequence?.length || 0;\n                    const start = Number(data.coordinate.start);\n                    const end = Number(data.coordinate.end);\n                    /**当start, end为0或者不存在时 */\n                    if (!start || !end) {\n                        return { verify: false, message: i18n.t(\"CoordinateMustBeLargerThan0\") };\n                    } /**当起始坐标超出范围时 */ else if (start < 1 || start > seqLen) {\n                        return {\n                            verify: false,\n                            message: i18n.t(\"BioTools.PositionVerify\", { type: i18n.t(\"BioTools.Start\"), start: 1, end: seqLen }),\n                        };\n                    } /**当终止坐标超出范围时 */ else if (end < 1 || end > seqLen) {\n                        return {\n                            verify: false,\n                            message: i18n.t(\"BioTools.PositionVerify\", { type: i18n.t(\"BioTools.End\"), start: 1, end: seqLen }),\n                        };\n                    } /**当起始大于结束时 */ else if (start > end) {\n                        return { verify: false, message: i18n.t(\"Placeholder.StartExceedEnd\") };\n                    } /**当片段大于20bp时 */ else if (end - start + 1 > 50) {\n                        return { verify: false, message: i18n.t(\"BioTools.MrnaVerify1\", { length: 50 }) };\n                    } else {\n                        return { verify: true, message: \"\" };\n                    }\n                },\n            },\n        ],\n        ref: [\n            {\n                trigger: \"verify\",\n                verify: (data: any) => {\n                    if (data.ref) return { verify: true, message: \"\" };\n                    else {\n                        return { verify: false, message: \"Please provide the coordinate\" };\n                    }\n                },\n            },\n        ],\n        alt: [\n            {\n                trigger: \"verify\",\n                verify: (data: any) => {\n                    if (data.alt && !/^([a|A|t|T|c|C|g|G]*)$/.test(data.alt)) {\n                        return { verify: false, message: \"only alphabet 'ATCG' are allowed\" };\n                    } else {\n                        return { verify: true, message: \"\" };\n                    }\n                },\n            },\n        ],\n    };\n\n    //* 函数列表\n    const methods = {\n        //* 初始化函数\n        init: (origin: any, dictionaries: any) => {\n            //* 重置表单\n            nodes.form.value?.reset();\n\n            //* 数据初始化\n            data.ref = \"\";\n            data.alt = \"\";\n            data.coordinate.end = undefined;\n            data.coordinate.start = undefined;\n\n            //* 数据缓存\n            refs.original.value = origin || {};\n            refs.dictionaries.value = dictionaries || {};\n        },\n\n        //* 焦点获取函数\n        focus: () => {\n            if (refs.show.value) return;\n            else {\n                requestAnimationFrame(() => nodes.alt.value?.focus());\n            }\n        },\n\n        //* 切换数据\n        changeData: function (origin: any) {\n            //* 重置表单\n            nodes.form.value?.reset();\n\n            //* 初始化基础数据\n            const end = origin?.range?.[1] || \"\";\n            const start = origin?.range?.[0] || \"\";\n            const ref = refs.dictionaries.value.sequence.slice(start - 1, end);\n\n            //* 初始化表单数据\n            refs.candidate.value = [];\n            data.coordinate.end = end;\n            data.coordinate.start = start;\n            data.ref = ref;\n            data.alt = origin.alt;\n\n            //* 检测点位是否合规\n            nodes.form.value?.validator((valid: boolean) => {\n                //* 校验失败, 退出\n                if (!valid) return;\n                //* 存在候选菜单\n                if (origin?.codons?.length) {\n                    //* 生成Codons候选菜单\n                    //* 遍历生成候选列表并计算最接近的alt\n                    let altNumber = 0;\n                    origin.codons.forEach((alt: string) => {\n                        //* 补充候选列表\n                        refs.candidate.value.push({ label: alt, value: alt });\n                        //* 临时计数变量\n                        let number = 0;\n                        //* 剪接字符列表\n                        const chars = alt?.split(\"\") || [];\n                        //* 遍历计数\n                        for (let i = 0; i < chars.length; i++) {\n                            if (ref == alt || !ref.charAt(i) || !alt.charAt(i)) return;\n                            if (ref.charAt(i) == alt.charAt(i)) number++;\n                        }\n                        //* 检测是否大于上个数\n                        if (number > altNumber) {\n                            data.alt = alt;\n                        }\n                    });\n\n                    //* 检测是否存在alt\n                    if (!data.alt) {\n                        data.alt = refs.candidate.value?.[0]?.value || \"\";\n                    }\n                }\n\n                //* 触发预览图更新\n                emit(\"redraw\", { start: data.coordinate.start, end: data.coordinate.end, alt: data.alt, ref: data.ref });\n            });\n        },\n\n        //* 切换预测位点\n        changeCoordinate: function () {\n            const hanlder = (valid: boolean) => {\n                const start = Number(data.coordinate.start) || 0;\n                const end = Number(data.coordinate.end) || 0;\n                if (valid) {\n                    data.ref = refs.dictionaries.value.sequence.slice(start - 1, end);\n                    emit(\"redraw\", {\n                        start: start,\n                        end: end,\n                        alt: data.alt && /^([A|T|C|G]*)$/.test(data.alt) ? data.alt : \"\",\n                        ref: data.ref,\n                    });\n                    nodes.form.value?.validator(() => {}, [\"ref\"]);\n                } else {\n                    data.ref = \"\";\n                }\n            };\n\n            nodes.form.value?.validator(hanlder, [\"coordinate\"]);\n        },\n\n        //* 切换Alteration\n        changeAlt: function () {\n            const hanlder = (valid: boolean) => {\n                if (valid) {\n                    emit(\"redraw\", { start: data.coordinate.start, end: data.coordinate.end, alt: data.alt, ref: data.ref });\n                }\n            };\n\n            data.alt = data.alt.toUpperCase();\n            if (data.coordinate.start && data.coordinate.end) {\n                nodes.form.value?.validator(hanlder, [\"coordinate\", \"alt\"]);\n            } else {\n                nodes.form.value?.validator(() => {}, [\"alt\"]);\n            }\n        },\n\n        //* 表单提交事件\n        submit: function (callBack: (data: any) => void) {\n            nodes.form.value?.validator((valid: boolean) => {\n                valid && callBack && callBack({ alt: data.alt, ref: data.ref, gene_pos: data.coordinate.start });\n            });\n        },\n    };\n\n    return { refs, data, nodes, rules, methods };\n};\n","<template>\n    <UiForm ref=\"form\" :data=\"data\" :rules=\"rules\">\n        <div class=\"row\">\n            <UiFormItem prop=\"coordinate\" :label=\"$t('Site')\">\n                <UiScopeInput name=\"coordinate\" v-model=\"data.coordinate\" :placeholder=\"cPlaceholder\" @change=\"changeCoordinate\" />\n            </UiFormItem>\n\n            <UiFormItem prop=\"ref\" :label=\"$t('ReferenceBase')\">\n                <UiInput name=\"ref\" v-model=\"data.ref\" :readonly=\"true\" placeholder=\"\" />\n            </UiFormItem>\n\n            <UiFormItem prop=\"alt\" :label=\"$t('Mutant')\">\n                <UiInput\n                    ref=\"alt\"\n                    name=\"alt\"\n                    v-model=\"data.alt\"\n                    :candidates=\"candidate\"\n                    :placeholder=\"$t('MutantSequence')\"\n                    @change=\"changeAlt\"\n                    @focus=\"nextTick(() => (show = true))\"\n                    @blur=\"nextTick(() => (show = false))\" />\n                <UiIcon class=\"row-arrow\" :class=\"{ active: show }\" v-show=\"candidate.length\" name=\"arrow\" @mousedown=\"methods.focus\" />\n            </UiFormItem>\n        </div>\n    </UiForm>\n</template>\n\n<script lang=\"ts\" setup>\nimport { UiIcon, UiForm, UiInput, UiFormItem, UiScopeInput } from \"various-ui\";\nimport { useComposable } from \"./src/composable\";\n\nconst emit = defineEmits<{ (event: \"redraw\", data: any): void }>();\n\nconst { refs, data, nodes, rules, methods } = useComposable(emit);\nconst { show, candidate, cPlaceholder } = refs;\nconst { form, alt } = nodes;\nconst { changeCoordinate, changeAlt } = methods;\n\ndefineExpose({ init: methods.init, submit: methods.submit, changeData: methods.changeData });\n</script>\n\n<style lang=\"less\" scoped>\n.ui-form {\n    .row {\n        display: flex;\n        margin-top: 24px;\n        justify-content: space-between;\n        .row-arrow {\n            top: 10px;\n            right: var(--uioption-form-spacing-x);\n            cursor: pointer;\n            position: absolute;\n            font-size: 20px;\n            transition: all 0.3s;\n            &.active {\n                transform: rotate(180deg);\n            }\n        }\n    }\n}\n</style>\n","export const naa: { label: string; value: string; shortnanme?: string }[] = [\n    { label: \"A (Ala)\", value: \"A\", shortnanme: \"Ala\" },\n    { label: \"R (Arg)\", value: \"R\", shortnanme: \"Arg\" },\n    { label: \"N (Asn)\", value: \"N\", shortnanme: \"Asn\" },\n    { label: \"D (Asp)\", value: \"D\", shortnanme: \"Asp\" },\n    { label: \"C (Cys)\", value: \"C\", shortnanme: \"Cys\" },\n    { label: \"Q (Gln)\", value: \"Q\", shortnanme: \"Gln\" },\n    { label: \"E (Glu)\", value: \"E\", shortnanme: \"Glu\" },\n    { label: \"G (Gly)\", value: \"G\", shortnanme: \"Gly\" },\n    { label: \"H (His)\", value: \"H\", shortnanme: \"His\" },\n    { label: \"I (Ile)\", value: \"I\", shortnanme: \"Ile\" },\n    { label: \"L (Leu)\", value: \"L\", shortnanme: \"Leu\" },\n    { label: \"K (Lys)\", value: \"K\", shortnanme: \"Lys\" },\n    { label: \"M (Met)\", value: \"M\", shortnanme: \"Met\" },\n    { label: \"F (Phe)\", value: \"F\", shortnanme: \"Phe\" },\n    { label: \"P (Pro)\", value: \"P\", shortnanme: \"Pro\" },\n    { label: \"S (Ser)\", value: \"S\", shortnanme: \"Ser\" },\n    { label: \"T (Thr)\", value: \"T\", shortnanme: \"Thr\" },\n    { label: \"W (Trp)\", value: \"W\", shortnanme: \"Trp\" },\n    { label: \"Y (Tyr)\", value: \"Y\", shortnanme: \"Tyr\" },\n    { label: \"V (Val)\", value: \"V\", shortnanme: \"Val\" },\n    { label: \"* (TERM)\", value: \"*\" },\n];\n\nexport const codons: { [name: string]: { label: string; value: string; codon: string[]; fullname: string; shortnanme: string } } = {\n    \"A\": { label: \"Ala\", value: \"A\", codon: [\"GCT\", \"GCC\", \"GCA\", \"GCG\"], fullname: \"Alanine\", shortnanme: \"Ala\" },\n    \"R\": { label: \"Arg\", value: \"R\", codon: [\"CGT\", \"CGC\", \"CGA\", \"CGG\", \"AGA\", \"AGG\"], fullname: \"Arginine\", shortnanme: \"Arg\" },\n    \"N\": { label: \"Asn\", value: \"N\", codon: [\"AAT\", \"AAC\"], fullname: \"Asparagine\", shortnanme: \"Asn\" },\n    \"D\": { label: \"Asp\", value: \"D\", codon: [\"GAT\", \"GAC\"], fullname: \"Aspartic acid\", shortnanme: \"Asp\" },\n    \"C\": { label: \"Cys\", value: \"C\", codon: [\"TGT\", \"TGC\"], fullname: \"Cysteine\", shortnanme: \"Cys\" },\n    \"Q\": { label: \"Gln\", value: \"Q\", codon: [\"CAA\", \"CAG\"], fullname: \"Glutamine\", shortnanme: \"Gln\" },\n    \"E\": { label: \"Glu\", value: \"E\", codon: [\"GAA\", \"GAG\"], fullname: \"Glutamic acid\", shortnanme: \"Glu\" },\n    \"G\": { label: \"Gly\", value: \"G\", codon: [\"GGT\", \"GGC\", \"GGA\", \"GGG\"], fullname: \"Glycine\", shortnanme: \"Gly\" },\n    \"H\": { label: \"His\", value: \"H\", codon: [\"CAT\", \"CAC\"], fullname: \"Histidine\", shortnanme: \"His\" },\n    \"I\": { label: \"Ile\", value: \"I\", codon: [\"ATT\", \"ATC\", \"ATA\"], fullname: \"Isoleucine\", shortnanme: \"Ile\" },\n    \"L\": { label: \"Leu\", value: \"L\", codon: [\"CTT\", \"CTC\", \"CTA\", \"CTG\", \"TTA\", \"TTG\"], fullname: \"Leucine\", shortnanme: \"Leu\" },\n    \"K\": { label: \"Lys\", value: \"K\", codon: [\"AAA\", \"AAG\"], fullname: \"Lysine\", shortnanme: \"Lys\" },\n    \"M\": { label: \"Met\", value: \"M\", codon: [\"ATG\"], fullname: \"Methionine\", shortnanme: \"Met\" },\n    \"F\": { label: \"Phe\", value: \"F\", codon: [\"TTT\", \"TTC\"], fullname: \"Phenylalanine\", shortnanme: \"Phe\" },\n    \"P\": { label: \"Pro\", value: \"P\", codon: [\"CCT\", \"CCC\", \"CCA\", \"CCG\"], fullname: \"Proline\", shortnanme: \"Pro\" },\n    \"S\": { label: \"Ser\", value: \"S\", codon: [\"TCT\", \"TCC\", \"TCA\", \"TCG\", \"AGT\", \"AGC\"], fullname: \"Serine\", shortnanme: \"Ser\" },\n    \"T\": { label: \"Thr\", value: \"T\", codon: [\"ACT\", \"ACC\", \"ACA\", \"ACG\"], fullname: \"Threonine\", shortnanme: \"Thr\" },\n    \"W\": { label: \"Trp\", value: \"W\", codon: [\"TGG\"], fullname: \"Tryptophan\", shortnanme: \"Trp\" },\n    \"Y\": { label: \"Tyr\", value: \"Y\", codon: [\"TAT\", \"TAC\"], fullname: \"Tyrosine\", shortnanme: \"Tyr\" },\n    \"*\": { label: \"TERM\", value: \"*\", codon: [\"TAA\", \"TAG\", \"TGA\"], fullname: \"Termination codon\", shortnanme: \"TERM\" },\n    \"V\": { label: \"Val\", value: \"V\", codon: [\"GTT\", \"GTC\", \"GTA\", \"GTG\"], fullname: \"Valine\", shortnanme: \"Val\" },\n};\n\nexport const codonDict: { [name: string]: string } = {\n    TTT: \"F\",\n    TTC: \"F\",\n    TTA: \"L\",\n    TTG: \"L\",\n    CTT: \"L\",\n    CTC: \"L\",\n    CTA: \"L\",\n    CTG: \"L\",\n    AGT: \"S\",\n    AGC: \"S\",\n    TCT: \"S\",\n    TCC: \"S\",\n    TCA: \"S\",\n    TCG: \"S\",\n    TAT: \"Y\",\n    TAC: \"Y\",\n    TGT: \"C\",\n    TGC: \"C\",\n    CCT: \"P\",\n    CCC: \"P\",\n    CCA: \"P\",\n    CCG: \"P\",\n    CAT: \"H\",\n    CAC: \"H\",\n    CAA: \"Q\",\n    CAG: \"Q\",\n    AGA: \"R\",\n    AGG: \"R\",\n    CGT: \"R\",\n    CGC: \"R\",\n    CGA: \"R\",\n    CGG: \"R\",\n    ATT: \"I\",\n    ATC: \"I\",\n    ATA: \"I\",\n    ACT: \"T\",\n    ACC: \"T\",\n    ACA: \"T\",\n    ACG: \"T\",\n    AAT: \"N\",\n    AAC: \"N\",\n    AAA: \"K\",\n    AAG: \"K\",\n    GTT: \"V\",\n    GTC: \"V\",\n    GTA: \"V\",\n    GTG: \"V\",\n    GCT: \"A\",\n    GCC: \"A\",\n    GCA: \"A\",\n    GCG: \"A\",\n    GAT: \"D\",\n    GAC: \"D\",\n    GAA: \"E\",\n    GAG: \"E\",\n    GGT: \"G\",\n    GGC: \"G\",\n    GGA: \"G\",\n    GGG: \"G\",\n    TGG: \"W\",\n    ATG: \"M\",\n    TAA: \"*\",\n    TAG: \"*\",\n    TGA: \"*\",\n};\n","import type { UiForm, UiTypes } from \"various-ui\";\n\nimport { codonDict, codons } from \"./options\";\n\nexport const useComposable = (emit: { (event: \"redraw\", data: any): void }) => {\n    //* 获取I18n\n    const i18n = useI18n();\n\n    //* 响应式变量\n    const refs = {\n        form: ref<InstanceType<typeof UiForm>>(),\n\n        dictionaries: ref<any>({}), //? 字典\n        candidate: ref<UiTypes.candidate[]>([]), //? 候选项\n        original: ref<any>({}), //? 原始数据\n    };\n\n    //* 表单数据\n    const data = reactive({\n        coordinate: \"\",\n        codon: \"\",\n        oaa: \"\",\n        naa: \"\",\n    });\n\n    //* 表单校验规则\n    const rules: { [name: string]: UiTypes.verifyRule[] } = {\n        oaa: [\n            {\n                trigger: \"change\",\n                verify: (data: any) => {\n                    if (data.oaa) return { verify: true, message: \"\" };\n                    else {\n                        return { verify: false, message: \"Please give us a original amino acid\" };\n                    }\n                },\n            },\n        ],\n        naa: [\n            {\n                trigger: \"change\",\n                verify: (data: any) => {\n                    if (!/^([A|R|N|D|C|Q|E|G|H|I|L|K|M|F|P|S|T|W|Y|V|*]*)$/.test(data.naa)) {\n                        return { verify: false, message: \"only alphabet 'ARNDCQEGHILKMFPSTWYV*' are allowed\" };\n                    } else {\n                        return { verify: true, message: \"\" };\n                    }\n                },\n            },\n        ],\n        coordinate: [\n            {\n                trigger: \"verify\",\n                verify: (data: any) => {\n                    const coordinate = Number(data.coordinate);\n                    if (!coordinate || coordinate < 1 || coordinate > refs.dictionaries.value.protein.length) {\n                        return { verify: false, message: \"Please input the position information\" };\n                    } else {\n                        return { verify: true, message: \"\" };\n                    }\n                },\n            },\n        ],\n    };\n\n    //* 函数列表\n    const methods = {\n        //* 初始化函数\n        init: function (origin: any, dictionaries: any) {\n            //* 重置表单\n            refs.form.value?.reset();\n\n            //* 数据初始化\n            data.naa = \"\";\n            data.oaa = \"\";\n            data.codon = \"\";\n            data.coordinate = \"\";\n\n            //* 数据缓存\n            refs.original.value = origin || {};\n            refs.dictionaries.value = dictionaries || {};\n        },\n\n        //* 切换预测位点\n        changePos: () => {\n            const handler = (valid: boolean) => {\n                const coordinate = Number(data.coordinate) || 0;\n                const protein = refs.dictionaries.value.protein[coordinate - 1];\n                if (valid && protein) {\n                    data.oaa = protein.value;\n                    refs.form.value?.validator(() => {}, [\"oaa\"]);\n                    if (data.codon && /^([a|A|t|T|c|C|g|G]*)$/.test(data.codon)) {\n                        emit(\"redraw\", { start: protein.start, end: protein.end, ref: protein.value, alt: data.codon });\n                    } else {\n                        emit(\"redraw\", { start: protein.start, end: protein.end, ref: protein.value });\n                    }\n                } else {\n                    data.oaa = \"\";\n                }\n            };\n\n            refs.form.value?.validator(handler, [\"coordinate\"]);\n        },\n\n        //* 切换Naa\n        changeNaa: function () {\n            const handler = (valid: boolean) => {\n                if (!valid) return;\n\n                const coordinate = Number(data.coordinate) || 0;\n                const protein = refs.dictionaries.value.protein[coordinate - 1];\n                const codon = codons[data.naa] || {};\n\n                refs.candidate.value = [];\n                (codon.codon || []).forEach((val) => {\n                    refs.candidate.value.push({ label: val, value: val });\n                });\n\n                if (data.naa == \"\") {\n                    protein && emit(\"redraw\", { start: protein.start, end: protein.end, ref: protein.value });\n                } else if (refs.candidate.value.length > 0) {\n                    let codonNumber = 0;\n                    let codon = refs.candidate.value[0].value;\n                    if (data.oaa) {\n                        refs.candidate.value.forEach((c) => {\n                            let number = 0;\n                            if (c.value == data.oaa) return;\n                            if (c.value.charAt(0) == data.oaa.charAt(0)) number++;\n                            if (c.value.charAt(1) == data.oaa.charAt(1)) number++;\n                            if (c.value.charAt(2) == data.oaa.charAt(2)) number++;\n                            if (number > codonNumber) {\n                                codon = c.value;\n                                codonNumber = number;\n                            }\n                        });\n                    }\n\n                    data.codon = codon;\n                    protein && emit(\"redraw\", { start: protein.start, end: protein.end, ref: protein.value, alt: data.codon });\n                }\n            };\n\n            refs.form.value?.validator(handler, [\"naa\"]);\n        },\n\n        //* 切换Codon\n        changeCodon: function () {\n            const coordinate = Number(data.coordinate) || 0;\n            const protein = refs.dictionaries.value.protein[coordinate - 1];\n            const naa = codonDict[data.codon];\n\n            refs.candidate.value = [];\n            if (naa) {\n                data.naa = naa;\n                const codon = codons[naa] || {};\n                (codon.codon || []).forEach((val) => {\n                    refs.candidate.value.push({ label: val, value: val });\n                });\n            } else {\n                data.naa = \"\";\n            }\n\n            data.codon = data.codon.toUpperCase();\n            refs.form.value?.validator(() => {}, [\"naa\"]);\n            protein && emit(\"redraw\", { start: protein.start, end: protein.end, ref: protein.value, alt: data.codon });\n        },\n\n        //* 表单提交事件\n        submit: function (callBack: (data: any) => void) {\n            refs.form.value?.validator((valid: boolean) => {\n                if (valid) {\n                    const coordinate = Number(data.coordinate) || 0;\n                    const protein = refs.dictionaries.value.protein[coordinate - 1];\n                    callBack && callBack({ alt: data.codon, ref: data.oaa, gene_pos: protein.start });\n                }\n            });\n        },\n    };\n\n    //* 计算属性\n    const computeds = {\n        oaa: computed(() => {\n            if (data.coordinate && data.oaa) {\n                const key = codonDict[data.oaa];\n                return `${key} (${codons[key].shortnanme}) : ${data.oaa}`;\n            }\n\n            return \"\";\n        }),\n    };\n\n    return { refs, data, rules, methods, computeds };\n};\n","<template>\n    <UiForm ref=\"form\" :data=\"data\" :rules=\"rules\">\n        <div class=\"row\">\n            <UiFormItem prop=\"coordinate\" :label=\"$t('Site')\">\n                <UiInput name=\"coordinate\" v-model=\"data.coordinate\" :width=\"200\" :placeholder=\"$t('BioTools.VPMPlaceholder1')\" @change=\"changePos\" />\n            </UiFormItem>\n\n            <UiFormItem prop=\"oaa\" :label=\"$t('BioTools.OAA')\">\n                <UiInput name=\"oaa\" v-model=\"data.oaa\" placeholder=\"\" :width=\"200\" :readonly=\"true\" />\n            </UiFormItem>\n\n            <UiFormItem prop=\"naa\" :label=\"$t('BioTools.NAA')\">\n                <UiSelect\n                    name=\"naa\"\n                    v-model=\"data.naa\"\n                    :classExtraName=\"css.candidates\"\n                    @change=\"changeNaa\"\n                    :width=\"200\"\n                    :height=\"306\"\n                    :candidates=\"naa\"\n                    :placeholder=\"$t('BioTools.NAA')\">\n                    <template #candidate=\"{ data }\">\n                        <div :class=\"css.item\">\n                            <div :class=\"css.content\">{{ data.value }}</div>\n                            <div :class=\"css.label\" v-if=\"data.shortnanme\">{{ data.shortnanme }}</div>\n                        </div>\n                    </template>\n                </UiSelect>\n            </UiFormItem>\n\n            <UiFormItem prop=\"codon\" :label=\"$t('BioTools.Codon')\">\n                <UiInput\n                    name=\"codon\"\n                    v-model=\"data.codon\"\n                    @change=\"changeCodon\"\n                    :width=\"200\"\n                    :candidates=\"candidate\"\n                    :placeholder=\"$t('BioTools.VPMPlaceholder2')\" />\n            </UiFormItem>\n        </div>\n    </UiForm>\n</template>\n\n<script lang=\"ts\" setup>\nimport { UiForm, UiInput, UiFormItem, UiSelect } from \"various-ui\";\nimport { useComposable } from \"./src/composable\";\nimport { naa } from \"./src/options\";\nimport css from \"./style/index.module.less\";\n\nconst emit = defineEmits<{ (event: \"redraw\", data: any): void }>();\n\nconst { refs, data, rules, methods } = useComposable(emit);\n\nconst { form, candidate } = refs;\nconst { changePos, changeNaa, changeCodon } = methods;\n\ndefineExpose({ init: methods.init, submit: methods.submit });\n</script>\n\n<style lang=\"less\" scoped>\n.ui-form {\n    .row {\n        display: flex;\n        margin-top: 24px;\n        justify-content: space-between;\n    }\n}\n</style>\n","import type { UiForm, UiTypes } from \"various-ui\";\n\nexport const useComposable = (emit: { (event: \"redraw\", data: any): void }) => {\n    //* 获取I18n\n    const i18n = useI18n();\n\n    //* 响应式变量\n    const refs = {\n        form: ref<InstanceType<typeof UiForm>>(),\n\n        dictionaries: ref<any>({}), //? 字典\n        original: ref<any>({}), //? 原始数据\n\n        cPlaceholder: { start: i18n.t(\"CdsStart\"), end: i18n.t(\"CdsEnd\") },\n    };\n\n    //* 表单数据\n    const data = reactive({\n        ref: \"\",\n        alt: \"\",\n        coordinate: {\n            \"start-steps\": 0,\n            \"end-steps\": 0,\n            \"start\": undefined,\n            \"end\": undefined,\n        },\n    });\n\n    //* 工具函数\n    const utils = {\n        disposePos: (value: number, next: number) => {\n            const n = isNaN(next) ? 0 : Number(next);\n            if (refs.dictionaries.value.cds[value - 1]) {\n                //* 在CDS字典中存在, 则返回真实坐标 + n\n                return refs.dictionaries.value.cds[value - 1].start + n;\n            } else if (refs.dictionaries.value.cds.length < value) {\n                //* 超出CDS字典长度, 则返回最后一个的真实坐标 + n\n                return refs.dictionaries.value.cds.slice(-1)[0].start + n;\n            } else {\n                //* 否则返回-1\n                return -1;\n            }\n        },\n    };\n\n    //* 表单校验规则\n    const rules: { [name: string]: UiTypes.verifyRule[] } = {\n        coordinate: [\n            {\n                trigger: \"change\",\n                verify: (data: any) => {\n                    const seqLen = refs.dictionaries.value?.sequence?.length || 0;\n                    const startSteps = Number(data.coordinate[\"start-steps\"]) || 0;\n                    const endSteps = Number(data.coordinate[\"end-steps\"]) || 0;\n                    const start = Number(data.coordinate.start) || 0;\n                    const end = Number(data.coordinate.end) || 0;\n\n                    const realStart = utils.disposePos(start, startSteps);\n                    const realEnd = utils.disposePos(end, endSteps);\n\n                    //* 当start, end不存在或超出范围时\n                    if (!realStart || realStart > seqLen) {\n                        return {\n                            verify: false,\n                            message: i18n.t(\"BioTools.PositionVerify\", {\n                                type: i18n.t(\"BioTools.Start\"),\n                                start: 1,\n                                end: refs.dictionaries.value.cds.length,\n                            }),\n                        };\n                    } else if (!realEnd || realEnd > seqLen) {\n                        return {\n                            verify: false,\n                            message: i18n.t(\"BioTools.PositionVerify\", {\n                                type: i18n.t(\"BioTools.End\"),\n                                start: 1,\n                                end: refs.dictionaries.value.cds.length,\n                            }),\n                        };\n                    } else if (realStart > realEnd) {\n                        //* 当起始大于结束时\n                        return { verify: false, message: i18n.t(\"Placeholder.StartExceedEnd\") };\n                    } else if (realEnd - realStart + 1 > 50) {\n                        //* 当片段大于20bp时\n                        return { verify: false, message: i18n.t(\"BioTools.MrnaVerify1\", { length: 50 }) };\n                    } else {\n                        return { verify: true, message: \"\" };\n                    }\n                },\n            },\n        ],\n        ref: [\n            {\n                trigger: \"verify\",\n                verify: (data: any) => {\n                    if (data.ref) return { verify: true, message: \"\" };\n                    else {\n                        return { verify: false, message: \"Please provide the coordinate\" };\n                    }\n                },\n            },\n        ],\n        alt: [\n            {\n                trigger: \"verify\",\n                verify: (data: any) => {\n                    if (data.alt && !/^([A|T|C|G]*)$/.test(data.alt)) {\n                        return { verify: false, message: \"only alphabet 'ATCG' are allowed\" };\n                    } else {\n                        return { verify: true, message: \"\" };\n                    }\n                },\n            },\n        ],\n    };\n\n    //* 函数列表\n    const methods = {\n        //* 初始化函数\n        init: function (origin: any, dictionaries: any) {\n            //* 重置表单\n            refs.form.value?.reset();\n\n            //* 数据初始化\n            data.ref = \"\";\n            data.alt = \"\";\n            data.coordinate.end = undefined;\n            data.coordinate.start = undefined;\n            data.coordinate[\"end-steps\"] = 0;\n            data.coordinate[\"start-steps\"] = 0;\n\n            //* 数据缓存\n            refs.original.value = origin || {};\n            refs.dictionaries.value = dictionaries || {};\n        },\n\n        //* submit事件\n        submit: function (callBack: (data: any) => void) {\n            const startSteps = Number(data.coordinate[\"start-steps\"]) || 0;\n            const start = Number(data.coordinate.start) || 0;\n            refs.form.value?.validator((valid: boolean) => {\n                valid && callBack && callBack({ alt: data.alt, ref: data.ref, gene_pos: utils.disposePos(start, startSteps) });\n            });\n        },\n\n        //* 切换Alteration\n        changeAlt: function () {\n            const startSteps = Number(data.coordinate[\"start-steps\"]) || 0;\n            const endSteps = Number(data.coordinate[\"end-steps\"]) || 0;\n            const start = Number(data.coordinate.start) || 0;\n            const end = Number(data.coordinate.end) || 0;\n\n            const realStart = utils.disposePos(start, startSteps);\n            const realEnd = utils.disposePos(end, endSteps);\n\n            const hanlder = (valid: boolean) => {\n                if (valid) {\n                    emit(\"redraw\", { ref: data.ref, alt: data.alt, end: realEnd, start: realStart });\n                }\n            };\n\n            data.alt = data.alt.toUpperCase();\n            if (realStart && realEnd) {\n                refs.form.value?.validator(hanlder, [\"coordinate\", \"alt\"]);\n            } else {\n                refs.form.value?.validator(() => {}, [\"alt\"]);\n            }\n        },\n\n        //* 切换预测位置\n        changeCoordinate: function () {\n            const hanlder = (valid: boolean) => {\n                if (valid) {\n                    const startSteps = Number(data.coordinate[\"start-steps\"]) || 0;\n                    const endSteps = Number(data.coordinate[\"end-steps\"]) || 0;\n                    const start = Number(data.coordinate.start) || 0;\n                    const end = Number(data.coordinate.end) || 0;\n\n                    const realStart = utils.disposePos(start, startSteps);\n                    const realEnd = utils.disposePos(end, endSteps);\n                    const ref = [];\n\n                    for (let i = realStart; i <= realEnd; i++) {\n                        ref.push(refs.dictionaries.value.sequence.charAt(i - 1));\n                    }\n\n                    data.ref = ref.join(\"\");\n                    const renderData = { start: realStart, end: realEnd, ref: data.ref, alt: \"\" };\n                    if (data.alt && /^([A|T|C|G]*)$/.test(data.alt)) {\n                        renderData.alt = data.alt;\n                    }\n\n                    emit(\"redraw\", renderData);\n                } else {\n                    data.ref = \"\";\n                }\n            };\n\n            refs.form.value?.validator(hanlder, [\"coordinate\"]);\n        },\n    };\n\n    return { refs, data, rules, methods };\n};\n","<template>\n    <UiForm ref=\"form\" :data=\"data\" :rules=\"rules\">\n        <div class=\"row\">\n            <UiFormItem prop=\"coordinate\" :label=\"$t('Site')\">\n                <UiStepsInput name=\"coordinate\" v-model=\"data.coordinate\" :width=\"408\" :placeholder=\"cPlaceholder\" @change=\"changeCoordinate\" />\n            </UiFormItem>\n\n            <UiFormItem prop=\"ref\" :label=\"$t('ReferenceBase')\">\n                <UiInput name=\"ref\" v-model=\"data.ref\" placeholder=\"\" :width=\"216\" :readonly=\"true\" />\n            </UiFormItem>\n\n            <UiFormItem prop=\"alt\" :label=\"$t('Mutant')\">\n                <UiInput name=\"alt\" v-model=\"data.alt\" :width=\"216\" :placeholder=\"$t('MutantSequence')\" @change=\"changeAlt\" />\n            </UiFormItem>\n        </div>\n    </UiForm>\n</template>\n\n<script lang=\"ts\" setup>\nimport { UiForm, UiInput, UiFormItem, UiStepsInput } from \"various-ui\";\nimport { useComposable } from \"./src/composable\";\n\nconst emit = defineEmits<{ (event: \"redraw\", data: any): void }>();\n\nconst { refs, data, rules, methods } = useComposable(emit);\n\nconst { form, cPlaceholder } = refs;\nconst { changeCoordinate, changeAlt } = methods;\n\ndefineExpose({ init: methods.init, submit: methods.submit });\n</script>\n\n<style lang=\"less\" scoped>\n.ui-form {\n    .row {\n        display: flex;\n        margin-top: 24px;\n        justify-content: space-between;\n    }\n}\n</style>\n","//* 组件库\nimport { $message, utility, $loading } from \"various-ui\";\n//* 公共组件\nimport type { ConfirmModal } from \"@/components/windows\";\n//* 公共函数\nimport { Formats } from \"@/assets/js\";\n//* 私有组件\nimport Gene from \"../components/gene/index.vue\";\nimport Protein from \"../components/protein/index.vue\";\nimport Transcript from \"../components/transcript/index.vue\";\nimport PreviewModel from \"./components/preview/index.vue\";\n//* 组件属性\nimport type { VPMInitOption, VPMFormData } from \"../index\";\n\nexport const useComposable = () => {\n    //* 获取i18n\n    const i18n = useI18n();\n\n    //* 获取Route\n    const route = useRoute();\n\n    //* 响应式变量\n    const refs = {\n        mrnas: ref<any[]>([]),\n        sequence: ref<string>(\"\"),\n        dictionaries: ref<{ [name: string]: any }>({}),\n    };\n\n    //* 表单数据\n    const data = reactive<VPMFormData>({\n        id: Formats.query(route.query.id), //? 基因ID\n        mode: \"Gene\", //? 当前模式\n        name: \"\", //? 基因名称\n        mrna: null, //? 当前选择的mrna\n        paste: \"\", //? 待解析的字符串\n        transcript: \"\", //? 转录本ID\n    });\n\n    //* 节点\n    const nodes = {\n        model: ref<InstanceType<typeof Gene>>(),\n        confirm: ref<InstanceType<typeof ConfirmModal>>(),\n        preview: ref<InstanceType<typeof PreviewModel>>(),\n    };\n\n    //* 工具函数\n    const utils = {\n        //* 数据处理函数\n        data: (response: any) => {\n            if (response?.data?.length) {\n                //* 数据初始化\n                data.name = response.name || \"--\";\n                refs.mrnas.value = [];\n                refs.sequence.value = response.sequence || \"\";\n                //* 生成转录本选择器配置项\n                response?.data?.forEach((mrna: any) => {\n                    refs.mrnas.value.push(Object.assign(mrna, { length: refs.sequence.value.length }));\n                });\n\n                //* 初始化选择器数据\n                data.mrna = refs.mrnas.value.find((value) => value.value == data.transcript) || refs.mrnas.value[0];\n                data.transcript = data.mrna.value;\n\n                //* 处理数据生成蛋白列表与CDS列表\n                utils.dictionaries();\n\n                //* 初始化输入模型与预览模型\n                nextTick(() => {\n                    nodes.model.value?.init(data, Object.assign(refs.dictionaries.value, { sequence: refs.sequence.value }));\n                    nodes.preview.value?.init(data.mrna);\n                    if (data.paste) {\n                        methods.mutation();\n                    }\n                });\n            } else {\n                $message.warning(i18n.t(\"Placeholder.GeneNotTranscript\"));\n            }\n        },\n\n        //* 生成CDS字典与蛋白字典\n        dictionaries: () => {\n            //* 初始化蛋白计数器\n            const config: any = { start: 0, end: 0, chars: [] };\n\n            //* 初始化字典\n            refs.dictionaries.value.cds = [];\n            refs.dictionaries.value.protein = [];\n\n            //- 3. 遍历CDS列表生成CDS字典与蛋白字典\n            data.mrna.cds.forEach((value: any) => {\n                for (let i = value[0]; i <= value[1]; i++) {\n                    const char = refs.sequence.value.charAt(i - 1);\n                    refs.dictionaries.value.cds.push({ start: i, value: char });\n                    if (config.chars.length == 3) {\n                        refs.dictionaries.value.protein.push(utility.cloneDeep(Object.assign(config, { value: config.chars.join(\"\") })));\n                        config.start = i;\n                        config.chars = [char];\n                    } else {\n                        config.chars.push(char);\n                        config.start = config.start || i;\n                        config.end = i;\n                    }\n                }\n            });\n\n            //- 4. 检测是否存在蛋白\n            if (config.chars.length == 3) {\n                refs.dictionaries.value.protein.push(utility.cloneDeep(Object.assign(config, { value: config.chars.join(\"\") })));\n            }\n        },\n\n        //* 表单提交函数\n        submit: (data: Object) => {\n            $loading.open({ message: i18n.t(\"UnderLoad\") });\n            api.frontend(\"/api/ai/mouse-pheno-predict\", {\n                data: data,\n                method: \"POST\",\n                success: (response) => {\n                    if (response) {\n                        window.open(routerResolve({ name: \"MousePhenoPredictResult\", params: { id: response } }).href as string, \"_blank\");\n                    } else {\n                        $message.warning(i18n.t(\"UnknownError\"));\n                    }\n                },\n                finally: () => {\n                    $loading.close();\n                },\n            });\n        },\n    };\n\n    //* 函数列表\n    const methods = {\n        //* 初始化函数\n        init: (option: VPMInitOption) => {\n            //* 开启加载器\n            $loading.open({ message: i18n.t(\"UnderLoad\"), delay: 200 });\n\n            //* 初始化数据\n            data.id = option.id;\n            data.paste = option.nucleotide || \"\";\n            data.transcript = option.transcript || \"\";\n            //* 数据获取\n            api.frontend(\"/api/gene/mrnas-info\", {\n                data: { id: data.id },\n                finally: () => $loading.close(),\n                success: (response) => {\n                    utils.data(response);\n                },\n            });\n        },\n\n        //* 切换Mrna\n        mrna: () => {\n            const mrna = refs.mrnas.value.find((val) => val.value === data.transcript);\n            //* 获取Mrna成功时触发输入模型的初始化函数\n            if (mrna) {\n                data.mrna = mrna;\n                data.paste = \"\";\n                utils.dictionaries();\n                //* 初始化输入模型与预览模型\n                nextTick(() => {\n                    nodes.model.value?.init(data, Object.assign(refs.dictionaries.value, { sequence: refs.sequence.value }));\n                    nodes.preview.value?.init(data.mrna);\n                });\n            }\n        },\n\n        //* 切换模式\n        mode: function () {\n            nextTick(() => {\n                //* 数据更新\n                data.paste = \"\";\n                //* 可视化模型更新\n                nodes.model.value?.init(data, Object.assign(refs.dictionaries.value, { sequence: refs.sequence.value }));\n                nodes.preview.value?.init(data.mrna);\n            });\n        },\n\n        //* 切换基因\n        change: (response: any) => {\n            //* 路由更新\n            routerPush({ name: \"MousePhenoPredict\", query: { id: response.id } });\n            //* 数据更新\n            methods.init({ id: response.id });\n        },\n\n        //* 表单提交\n        submit: function () {\n            nodes.model.value?.submit((res: any) => {\n                const result = Object.assign(res, { name: data.name, gene_id: data.id, transcript_id: data.transcript });\n                if (!result.alt) nodes.confirm.value?.open(result);\n                else {\n                    utils.submit(result);\n                }\n            });\n        },\n\n        //* 解析突变信息\n        mutation: function () {\n            //* 无效数据检测\n            if (!data.paste) return;\n            //* 发起请求\n            $loading.open({ message: \"\", delay: 200 });\n            //* 突变位点解析\n            api.frontend(\"/api/mutations/analyze\", {\n                data: { id: data.id, keyword: data.paste, transcript: data.transcript },\n                method: \"POST\",\n                finally: () => $loading.close(),\n                success: (response) => {\n                    if (data.mode == \"Gene\") {\n                        //* 当前模式为Gene模式时直接切换表格数据\n                        nodes.model.value?.changeData(response);\n                    } else {\n                        //* 反之切换模式并初始化预览模型和切换表格数据\n                        data.mode = \"Gene\";\n                        nextTick(() => {\n                            nodes.model.value?.init(data, Object.assign(refs.dictionaries.value, { sequence: refs.sequence.value }));\n                            nodes.model.value?.changeData(response);\n                            nodes.preview.value?.init(data.mrna);\n                        });\n                    }\n                },\n            });\n        },\n    };\n\n    //* 计算属性\n    const computeds = {\n        view: computed(() => {\n            switch (data.mode) {\n                case \"Protein\":\n                    return Protein;\n                case \"Transcript\":\n                    return Transcript;\n                default:\n                    return Gene;\n            }\n        }),\n    };\n\n    return { data, refs, nodes, utils, methods, computeds };\n};\n","<template>\n    <!-- * 内容区域 -->\n    <div class=\"vpm-input container\">\n        <!-- 顶部模块 -->\n        <section class=\"vpm-header\">\n            <div class=\"vpm-title title-2 font-bold\">{{ $t(\"MousePhenoPredict\") }}</div>\n            <div class=\"vpm-controls\">\n                <div class=\"vpm-control\">\n                    <div class=\"control-label\">{{ $t(\"Layout.TypeName\", { type: \"Gene\", count: 0 }) }}</div>\n                    <div class=\"control-main\">\n                        <DefaultSearch\n                            v-model=\"data.name\"\n                            :width=\"264\"\n                            mode=\"select\"\n                            type=\"gene\"\n                            :query=\"{ tax_names: ['Mouse'] }\"\n                            @search=\"methods.change\" />\n                    </div>\n                </div>\n\n                <div class=\"vpm-control\">\n                    <div class=\"control-label\">{{ $t(\"TranscriptID\") }}</div>\n                    <div class=\"control-main\">\n                        <UiSelect\n                            v-model=\"data.transcript\"\n                            :candidates=\"mrnas\"\n                            :readonly=\"mrnas.length == 0\"\n                            :placeholder=\"$t('Placeholder.FilterBy')\"\n                            @change=\"methods.mrna\" />\n                    </div>\n                </div>\n            </div>\n        </section>\n\n        <!-- 预览模块 -->\n        <section class=\"vpm-main\">\n            <!-- 预览可视化模型 -->\n            <PreviewModel ref=\"preview\" />\n\n            <!-- 数据粘贴模块 -->\n            <div class=\"vpm-paste\">\n                <UiInput v-model=\"data.paste\" class=\"paste-input\" :width=\"264\" :placeholder=\"$t('EnterMutation')\" @change=\"methods.mutation\" />\n                <UiTooltip theme=\"dark\" class=\"paste-levitate\">\n                    <template #default><UiIcon name=\"question-mark\" class=\"paste-icon\" /></template>\n                    <template #content>\n                        <ul>\n                            <li style=\"font-weight: 700\">{{ $t(\"ExampleData\", 2) }}:</li>\n                            <li>1、g.12G>C</li>\n                            <li>2、c.123G>A</li>\n                            <li>3、c.123_124TG>C</li>\n                            <li>4、c.169+2T>C</li>\n                            <li>5、c.45_46insGC</li>\n                            <li>6、c.36_38del</li>\n                            <li>7、c.45_48delinsTT</li>\n                            <li>8、c.-1G>T</li>\n                            <li>9、c.*16G>T</li>\n                            <li>10、c.23+4_23+5GG>CT</li>\n                            <li>11、p.A3F(GCT>TTT)</li>\n                            <li>12、p.R75X</li>\n                            <li>13、IVS2+1</li>\n                        </ul>\n                    </template>\n                </UiTooltip>\n            </div>\n\n            <div class=\"vpm-components\">\n                <!-- 单选按钮组 -->\n                <UiRadioGroup class=\"vpm-radios\" v-model=\"data.mode\" @change=\"methods.mode\">\n                    <UiRadio value=\"Gene\">{{ $t(\"Gene\") }}</UiRadio>\n                    <UiRadio value=\"Transcript\">{{ $t(\"Transcript\") }}</UiRadio>\n                    <UiRadio value=\"Protein\">{{ $t(\"Protein\") }}</UiRadio>\n                </UiRadioGroup>\n\n                <!-- 模型组 -->\n                <component ref=\"model\" class=\"vpm-model\" :is=\"view\" @redraw=\"(data: any) => preview.drawPos(data)\"></component>\n            </div>\n        </section>\n\n        <section class=\"vpm-footer\">\n            <UiButton @click=\"methods.submit\" size=\"middle\">{{ $t(\"Prediction\") }}</UiButton>\n        </section>\n    </div>\n\n    <!-- * 确认窗口 -->\n    <confirm-modal ref=\"confirm\" @confirm=\"(data) => utils.submit(data)\" :content=\"$t('PredictionMutationDELConfirm')\" />\n</template>\n\n<script lang=\"ts\" setup>\n//* 组件库\nimport { UiRadioGroup, UiSelect, UiButton, UiRadio, UiInput, UiIcon, UiTooltip } from \"various-ui\";\n//* 公共组件\nimport { DefaultSearch } from \"@/components/controls\";\nimport { ConfirmModal } from \"@/components/windows\";\n//* 私有组件\nimport PreviewModel from \"./components/preview/index.vue\";\n//* 组件属性\nimport { useComposable } from \"./src/composable\";\n\n//* 插件\nconst route = useRoute();\n\n//* 组合函数\nconst { data, refs, nodes, utils, methods, computeds } = useComposable();\nconst { mrnas } = refs;\nconst { confirm, preview, model } = nodes;\nconst { view } = computeds;\n\ndefineExpose({ init: methods.init });\nonMounted(() => {\n    if (route.query.uuid) return;\n    else {\n        methods.init({ id: data.id });\n    }\n});\n</script>\n\n<style lang=\"less\" scoped>\n@import url(\"./index.less\");\n</style>\n","<template>\n    <NuxtLayout name=\"main\" :dark=\"true\" 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